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PrPSc Proteins
Concept
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Mastrianni, James A.
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An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregates.
Academic Article
Why?
Cytosolic prion protein toxicity is independent of cellular prion protein expression and prion propagation.
Academic Article
Why?
Generation of a new form of human PrP(Sc) in vitro by interspecies transmission from cervid prions.
Academic Article
Why?
Generation of human chronic wasting disease in transgenic mice.
Academic Article
Why?
Identifying key components of the PrPC-PrPSc replicative interface.
Academic Article
Why?
Live cell fluorescence resonance energy transfer predicts an altered molecular association of heterologous PrPSc with PrPC.
Academic Article
Why?
Onset of accumulation of PrPres in murine ME7 scrapie in relation to pathological and PrP immunohistochemical changes.
Academic Article
Why?
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein.
Academic Article
Why?
Prion protein conformation in a patient with sporadic fatal insomnia.
Academic Article
Why?
The AGAAAAGA palindrome in PrP is required to generate a productive PrPSc-PrPC complex that leads to prion propagation.
Academic Article
Why?
The charge structure of helix 1 in the prion protein regulates conversion to pathogenic PrPSc.
Academic Article
Why?
Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses.
Academic Article
Why?
Biochemical fingerprints of prion infection: accumulations of aberrant full-length and N-terminally truncated PrP species are common features in mouse prion disease.
Academic Article
Why?
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